Personally, I say take the time to go through them all if you see they sent a somewhat personal message. If its a copy and paste job, feel free to reciprocate that energy. I know some people are very strict about how they approach this and my main things are: 1) I am looking for 'THE' job, not a job. The more applications I have out there, the more options I have to pick from. 2) Protect my time. I reciprocate the energy the recruiters give me. If they wrote a very good note and seem interested in talking, I have a hunch they will go above and beyond to help me help them. If they are sending a automated "role in x city, are you free for a call"- I send them a generic response and see if they even follow up. 3) I forward opps to other people if I pass on them because idk, good karma