A couple years ago I moved from a large biotech in San Diego to a large tech company in Seattle. The job level was about the same. My title actually was downgraded by a level. But the total compensation was about 80% more. It should be noted though that my biotech job had better work/life balance. But I think on the whole for me it was a good choice to take the tech job. In my view, biotech will never pay as much as tech, because the biotech employees are more likely find their jobs meaningful and fulfilling, and as a result they are willing to accept lower compensation. The management knows this and they take full advantage.